Deinococcus radiodurans, also called “Conan the Bacteria” for its extraordinary ability to tolerate the harshest conditions, can withstand radiation doses thousands of times higher than what would kill a human – or any other organism for that matter.


The secret behind this impressive resistance is the presence of a collection of simple metabolites, which together with manganese form a powerful antioxidant. Now chemists from Northwestern University and the Uniformed Services University (USU) have discovered how this antioxidant works.


In a new study, researchers characterized a synthetic designer antioxidant called MDP that was inspired by the resilience of Deinococcus radiodurans. They found that the components of MDP – manganese ions, phosphate and a small peptide – form a ternary complex that is a much more powerful protector against radiation damage than manganese in combination with any of the other individual components alone.


This discovery could ultimately lead to new synthetic antioxidants specifically tailored to human needs. Applications include protecting astronauts from intense cosmic radiation during deep space missions, preparing for radiation emergencies, and producing radiation-inactivated vaccines.


The research will be published the week of December 9 in the Proceedings of the National Academy of Sciences.


“It is this ternary complex that is MDP’s excellent shield against the effects of radiation,” Northwestern’s said Brian Hoffman who conducted the research together with Michael Daly of USU. “We have long known that manganese ions and phosphate together form a strong antioxidant, but discovering and understanding the ‘magic’ power provided by the addition of the third component is a breakthrough. This study has provided the key to understanding why this combination is so. such a powerful – and promising – radioprotectant.”


Hoffman is the Charles E. and Emma H. ​​Morrison Professor of Chemistry and professor of molecular biosciences at Northwestern’s University. Weinberg College of Arts and Sciences . He is also a member of the Institute for Chemistry of Life Processes . Daly is an expert on Deinococcus radiodurans, a professor of pathology at USU and a member of the National Academies’ Committee on Planetary Protection.


Incredible Hulk of the microbial world


The new study builds on previous research from Hoffman and Daly’s collaboration, in which they attempted to evaluate the predicted ability of Deinococcus radiodurans to withstand radiation on Mars . In that study, Hoffman’s team at Northwestern used an advanced spectroscopy technique to measure the accumulation of manganese antioxidants in the microbes’ cells.


According to Hoffman and Daly, the size of the radiation dose that a microorganism or its spores can survive is directly related to the amount of manganese antioxidants it contains. In other words, more manganese antioxidants mean more resistance to intense radiation.


In previous studies, other researchers found that Deinococcus radiodurans can survive 25,000 grays (or units of X-rays and gamma rays). But inside their 2022 study Hoffman and Daly discovered that the bacteria – when dried and frozen – can withstand 140,000 gray radiation, a dose 28,000 times greater than what would kill a human. So if there are dormant, frozen microbes buried on Mars, they could possibly have survived the onslaught of galactic cosmic rays and solar protons to this day.


The power of three


Building on their efforts to understand the microbe’s radiation resistance, Hoffman and Daly’s team examined a designer decapeptide called DP1. In combination with phosphate and manganese, DP1 forms the free radical scavenger MDP, which successfully protects cells and proteins against radiation damage. In another recent study Daly and his collaborators found that MDP is effective in the preparation of irradiated polyvalent vaccines.


Using advanced paramagnetic resonance spectroscopy, the team revealed that MDP’s active ingredient is a ternary complex: a precise collection of phosphate and peptide bound to manganese.


“This new understanding of MDP could lead to the development of even more powerful manganese-based antioxidants for applications in healthcare, industry, defense and space exploration,” Daly said.


The study: “The ternary complex of Mn2+synthetic decapeptide DP1 (DEHGTAVMLK) and orthophosphate is an excellent antioxidant” was supported by the National Institutes of Health (grant number GM111097), the National Science Foundation (grant number CHE-2333907), and the Defense Threat Reduction Agency (grant number HDTRA1620354).




/Public publication. This material from the original organization/author(s) may be contemporary in nature and has been edited for clarity, style and length. Mirage.News takes no institutional positions or parties, and all views, opinions and conclusions expressed herein are solely those of the author(s). View the full document here.



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Nebraska medical marijuana legalization is closer to reality after judge's ruling but an appeal is likely
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Nebraska medical marijuana legalization is closer to reality after judge's ruling but an appeal is likely
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Nebraska medical marijuana legalization is closer to reality after judge's ruling but an appeal is likely
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US woman finds marijuana instead of burrito in package she ordered from Uber Eats
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Nebraska judge's ruling edges the state closer to legalizing medical marijuana - ABC News
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Nebraska judge's ruling edges the state closer to legalizing medical marijuana - WDRB
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Lancaster County District Court rules decision to legalize medical marijuana in Nebraska should s...
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Discounts and Best Deals for cannabis products online | 50% Off Everything (Excludes Accessories)
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urban-gro Expands Cannabis Sector Offering with Launch of New Processing and Extraction Division
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Nebraska judge's ruling edges the state closer to legalizing medical marijuana - Delta Optimist
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Nebraska judge’s ruling moves the state closer to legalizing medical marijuana - Toronto Star
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Nebraska judge’s ruling edges the state closer to legalizing medical marijuana - Toronto Star
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Nebraska medical marijuana legalization is closer to reality after judge’s ruling but an appeal is likely - KOB 4
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Nebraska judge dismisses challenges against medical marijuana petitions - Omaha World-Herald
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Lectures on Tap - "The History of Cannabis" Tickets, Tue, Dec 3, 2024 at 6:30 PM
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Verdict reached in case over legality of medicinal marijuana in Nebraska
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YouTube's High Science Is A Must-Watch For Cannabis Enthusiasts - Benzinga
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Nebraska judge sides with medical marijuana advocates in petition signature case
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Alcoholic Beverage and Cannabis Administration padlocks 14th illegal cannabis business’ doors in DC - DC News Now | Washington, DC
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Ohio's embrace of legal weed driving push for OSP to get new drug detection tool - MSN
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Florida Cannabis Industry Expands with New Vertical Licenses: Full List of Winners - stupidDOPE.com
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Mankato city council passes cannabis retail ordinances - KEYC
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Verdict reached in case over legality of medicinal marijuana in Nebraska - Nebraska Public Media | News
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Nebraska voters decision to legalize medical marijuana will stand - KETV
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Two applicants from Owensboro among first selectees for medical cannabis dispensary licenses
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Kentucky Awards First Medical Cannabis Dispensary Licenses - Benzinga
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Ohio's embrace of legal weed driving push for OSP to get new drug detection tool - WLWT Cincinnati
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Judge rules in favor of Nebraska medical marijuana petitioners - WOWT
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Democrats Make Last Plea to Biden to Change Marijuana Law Before Trump
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District judge sides with Nebraska medical cannabis ballot sponsors in legal challenge
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B.C. crime news: Illicit cannabis, submachine-guns seized from West Van home | Vehicles, home damaged in Pitt Meadows shooting - MSN
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Democrats Call On Biden to Limit Marijuana Prosecutions Before End of Term
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You Won A Delaware Cannabis License: Now What? | Canna Advisors
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Community Resource Fair - Cannabis Use Effects on Young Brains - YouTube
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Democrats Call On Biden to Limit Marijuana Prosecutions Before End of Term - Common Dreams
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District judge sides with Nebraska medical cannabis ballot sponsors in legal challenge - Nebraska Examiner
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How Marijuana Seeds Can Help For Everyday Medicine - gdhsgd.webworker-ag.de
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Federal Health Officials 'Rejected' DEA's Request To Testify At Marijuana Rescheduling ...
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Flatliners - by Todd Harrison - Cannabis Confidential - Substack
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urban-gro Expands Cannabis Sector Offering with Launch of New Processing and Extraction Division - AccessWire
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Landlord faces £10,000 bill after tenants turn rental into cannabis farm - The Telegraph
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Democrats Make Last Plea to Biden to Change Marijuana Law Before Trump - The New Republic
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Cannabis wholesale platform LeafLink buys Leaf Trade - Marijuana Business Daily
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Cannabis license lottery on hold in Minnesota - ABC 6 News - kaaltv.com
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What to expect from next week’s cannabis rescheduling hearing
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Bellevue family 'ecstatic' over medical marijuana lawsuit's dismissal
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Trump's CDC Pick Dave Weldon A Setback For Marijuana Policy - GreenPharms
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Kentucky awards 1st medical cannabis licenses to 36 dispensaries around the state - WDRB
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St. Louis County Board approves cannabis ordinance - WDIO
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Carlton County bans marijuana consumption in public spaces - Cloquet Pine Journal
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DEA Posts Details On Next Week's Marijuana Rescheduling Hearing, Including Live Stream ...
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DEA to Hold Hearing on the Rescheduling of Marijuana
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Four Northern Kentucky businesses awarded medical marijuana dispensary licenses - Cincinnati Business Courier
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Federal Marijuana Banking Legislation Could Still Pass By Year’s End, But Time is Running Out
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Germany-bound traveller from Canada caught carrying 45 kilos of weed in her luggage: Toronto Airport RCMP - CP24
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Medical Cannabis Dispensary Lottery Awards Several Businesses In West Kentucky | WKDZ
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Ohio Lawmakers Want to Make Cannabis Illegal Again
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City Council introduces ordinance which amends marijuana licensing - WTVB
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Nebraska judge's ruling moves the state closer to legalizing medical marijuana
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Man gets 13 years for importing cannabis - Cyprus Mail
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Ohio Bill Would Crack Down on Intoxicating Hemp Products
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Ohio Bill Would Crack Down on Intoxicating Hemp Products - Cleveland Scene
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Pair convicted on cannabis charges to be deported - BBC
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What's next for Nebraska medical cannabis, paid sick leave, abortion, school choice
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New York's Legal Marijuana Market Set To Pass $1 Billion In Sales By End Of 2024
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Kentucky Holds Lottery To Award First Medical Marijuana Dispensary Licenses
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Biden Should Expand Marijuana Pardons And Issue New Cannabis Prosecution Memo Before His Term Ends, Lawmakers Say - Marijuana Moment
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Marijuana education program draws interest at Bellarmine University - The Courier-Journal
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Thrive Capital, Tiger Global-Backed Cannabis Wholesale Platform LeafLink Buys Leaf Trade: Co. Will Process ~$9B In Annual GMV - Benzinga
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Florida approves 22 applicants for medical marijuana dispensary licenses
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Sioux Falls woman cited for weed, more - nwestiowa.com
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How Ohio’s recreational marijuana sales compare to Michigan
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Mankato limits cannabis retailers to four, sets strict zoning rules
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Pair convicted on cannabis charges to be deported to Malaysia - BBC
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Teens learn about the dangers of cannabis and smoking while having fun - NNSL Media
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Federal Policy Could Add $3 Billion To Cannabis Industry: On Track To Reach $55 Billion By 2030 - Benzinga
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Students learn about the dangers of cannabis - The Southern News
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Nebraska Judge Dismisses Legal Challenge to Medical Marijuana Initiatives Approved by Voters
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